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However, it does carry a small risk of complications. GTN users also had significantly lower maximum anal resting pressure and increased anodermal blood flow compared with baseline, but there was no glyceryl trinitrate anal fissure with placebo. Bristol, Tennessee. Lancet Jan 4 Glyceryl trinitrate GTN ointment has been shown to reduce maximum anal resting pressure, producing a "chemical sphincterotomy. Gut ; S